System for closed transfer of fluids having connector

ABSTRACT

A system includes a syringe adapter having a first end and a second end with the first end of the syringe adapter configured to be connected to a first container and the second end of the syringe adapter including a lock member having an open position and a closed position. The system also includes a vial adapter having a first end and a second end with the second end of the vial adapter configured to be connected to a second container and the first end of the vial adapter having a locking surface. The lock member includes at least one projection that extends radially outward. The syringe adapter has at least one corresponding projection configured to engage the at least one projection of the lock member to retain the lock member to the syringe adapter.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to U.S. Provisional Application Ser.No. 61/900,623, filed Nov. 6, 2013, which is hereby incorporated byreference in its entirety.

BACKGROUND OF THE INVENTION

1. Field of the Disclosure

The present disclosure relates generally to a system for the closedtransfer of fluids. More particularly, the present disclosure relates toa system that provides leak-proof sealing and pressure equalizationduring engagement of a cannula with a vial, during transfer of asubstance from a vial chamber to a barrel chamber via the cannula, andduring disengagement of the cannula from the vial.

2. Description of the Related Art

Health care providers reconstituting, transporting, and administeringhazardous drugs, such as cancer treatments, can put health careproviders at risk of exposure to these medications and present a majorhazard in the health care environment. For example, nurses treatingcancer patients risk being exposed to chemotherapy drugs and their toxiceffects. Unintentional chemotherapy exposure can affect the nervoussystem, impair the reproductive system, and bring an increased risk ofdeveloping blood cancers in the future. In order to reduce the risk ofhealth care providers being exposed to toxic drugs, the closed transferof these drugs becomes important.

Some drugs must be dissolved or diluted before they are administered,which involves transferring a solvent from one container to a sealedvial containing the drug in powder or liquid form, by means of a needle.Drugs may be inadvertently released into the atmosphere in gas form orby way of aerosolization, during the withdrawal of the needle from thevial and while the needle is inside the vial if any pressuredifferential between the interior of the vial and the surroundingatmosphere exists.

SUMMARY OF THE INVENTION

In one aspect, a system, such as a system for the closed transfer offluids, includes a syringe adapter having a first end and a second endwith the first end of the syringe adapter configured to be connected toa first container and the second end of the syringe adapter including alock member having an open position and a closed position. The systemalso includes a vial adapter having a first end and a second end withthe second end of the vial adapter configured to be connected to asecond container and the first end of the vial adapter having a lockingsurface. The syringe adapter is configured to be mated with the vialadapter when the lock member is in the open position and is configuredto be locked to the vial adapter when the lock member is in the closedposition and positioned adjacent to the locking surface. The lock memberincludes at least one projection that extends radially outward. Thesyringe adapter has at least one corresponding projection configured toengage the at least one projection of the lock member to retain the lockmember to the syringe adapter.

The system may also include a patient connector having a first end and asecond end and defining a passageway with the first end of the patientconnector including a locking surface configured to engage the lockmember of the syringe adapter and the second end of the patientconnector configured to be secured to a patient IV line. The syringeadapter may comprise a body and a seal arrangement positioned within thebody with the seal arrangement having at least one membrane andconfigured to move within the body of the syringe adapter. The vialadapter may comprise a pressure equalization arrangement and a spike.The body of the syringe adapter may define an opening extendingtransversely relative to a longitudinal axis of the syringe adapter thatreceives the lock member with the lock member configured to moverelative to the body of the syringe adapter between the open positionand the closed position. The lock member may include a biasing memberthat is configured to bias the lock member towards the closed position.The lock member may include a lead-in surface that is configured tocontact the second end of the vial adapter and move the lock member fromthe closed position to the open position when the syringe adapter ismated with the vial adapter.

The biasing member of the lock member may comprise a cantilever springwith the body of the syringe adapter defining a cam surface configuredto engage the cantilever spring of the lock member. The cantileverspring may extend in an axial direction with the cam surface extendingradially outward from the body of the syringe adapter. The at least oneprojection of the lock member may comprise a pair of projectionspositioned on opposite sides of the lock member, and the at least onecorresponding projection of the syringe adapter may comprise a pair ofcorresponding projections configured to engage the pair of projectionsof the lock member. The lock member may be annular and received withinan opening defined by the body of the syringe adapter with the openingof the syringe adapter extending transversely relative to a longitudinalaxis of the syringe adapter. The lock member may include a button thatis configured to be engaged by a hand of a user of the syringe adapterto move the lock member from the closed position to the open position.The seal arrangement may comprise a membrane carrier having a membranewith the first end of the vial adapter having a membrane configured toengage the membrane of the membrane carrier. The membrane carrier may bebiased toward the second end of the syringe adapter via biasing member.The first end of the syringe adapter may include a female luer connectorconfigured to be secured to a syringe.

BRIEF DESCRIPTION OF THE DRAWINGS

The above-mentioned and other features and advantages of thisdisclosure, and the manner of attaining them, will become more apparentand the disclosure itself will be better understood by reference to thefollowing descriptions of aspects of the disclosure taken in conjunctionwith the accompanying drawings, wherein:

FIG. 1 is a perspective view of a system according to one aspect of thepresent invention.

FIG. 2 is an exploded, perspective view of the system of FIG. 1according to one aspect of the present invention.

FIG. 3 is a perspective view of a syringe adapter of the system of FIG.1 according to one aspect of the present invention.

FIG. 4 is a front view of the syringe adapter of FIG. 3 according to oneaspect of the present invention.

FIG. 5 is a left side view of the syringe adapter of FIG. 3 according toone aspect of the present invention.

FIG. 6 is a rear view of the syringe adapter of FIG. 3 according to oneaspect of the present invention.

FIG. 7 is a top view of the syringe adapter of FIG. 3 according to oneaspect of the present invention.

FIG. 8 is a right side view of the syringe adapter of FIG. 3 accordingto one aspect of the present invention.

FIG. 9 is a bottom view of the syringe adapter of FIG. 3 according toone aspect of the present invention.

FIG. 10 is a cross-sectional view of the syringe adapter along line10-10 in FIG. 6 according to one aspect of the present invention.

FIG. 11 is a cross-sectional view of the syringe adapter along line11-11 in FIG. 5 according to one aspect of the present invention.

FIG. 12 is an enlarged perspective view of the syringe adapter of FIG. 3according to one aspect of the present invention.

FIG. 13 is a top perspective view of a lock member of the syringeadapter of FIG. 3 according to one aspect of the present invention.

FIG. 14 is bottom perspective view of the lock member shown in FIG. 13according to one aspect of the present invention.

FIG. 15 is a front perspective view of a vial adapter of the system ofFIG. 1 according to one aspect of the present invention.

FIG. 16 is a front view of the vial adapter of FIG. 15 according to oneaspect of the present invention.

FIG. 17 is a bottom perspective view of the vial adapter of FIG. 15according to one aspect of the present invention.

FIG. 18 is a top perspective view of the vial adapter of FIG. 15according to one aspect of the present invention.

FIG. 19 is a cross-sectional view of the vial adapter along line 19-19in FIG. 16 according to one aspect of the present invention.

FIG. 20 is a front perspective view of a patient connector of the systemof FIG. 1 according to one aspect of the present invention.

FIG. 21 is a cross-sectional view of the patient connector taken alongline 21-21 in FIG. 20 according to one aspect of the present invention.

FIG. 22 is a cross-sectional view of the syringe adapter of FIG. 3 priorto being connected to the vial adapter of FIG. 15 according to oneaspect of the present invention.

FIG. 23 is a cross-sectional view of the syringe adapter of FIG. 3 inthe process of being connected to the vial adapter of FIG. 15 accordingto one aspect of the present invention.

FIG. 24 is a cross-sectional view of the syringe adapter of FIG. 3connected and locked to the vial adapter of FIG. 15 according to oneaspect of the present invention.

FIG. 25 is a perspective view of a system according to a second aspectof the present invention.

FIG. 26 is a cross-sectional view of a vial adapter of the system ofFIG. 25 according to one aspect of the present invention.

FIG. 27 is a cross-sectional view of a syringe adapter of the system ofFIG. 25 according to one aspect of the present invention.

FIG. 28 is a cross-sectional view of a syringe adapter according to afurther aspect of the present invention.

FIG. 29 is a front view of a vial adapter according to yet anotheraspect of the present invention.

Corresponding reference characters indicate corresponding partsthroughout the several views. The exemplifications set out hereinillustrate exemplary aspects of the disclosure, and suchexemplifications are not to be construed as limiting the scope of thedisclosure in any manner.

DETAILED DESCRIPTION

The following description is provided to enable those skilled in the artto make and use the described aspects contemplated for carrying out theinvention. Various modifications, equivalents, variations, andalternatives, however, will remain readily apparent to those skilled inthe art. Any and all such modifications, variations, equivalents, andalternatives are intended to fall within the spirit and scope of thepresent invention.

For purposes of the description hereinafter, the terms “upper”, “lower”,“right”, “left”, “vertical”, “horizontal”, “top”, “bottom”, “lateral”,“longitudinal”, and derivatives thereof shall relate to the invention asit is oriented in the drawing figures. However, it is to be understoodthat the invention may assume various alternative variations, exceptwhere expressly specified to the contrary. It is also to be understoodthat the specific devices illustrated in the attached drawings, anddescribed in the following specification, are simply exemplary aspectsof the invention. Hence, specific dimensions and other physicalcharacteristics related to the aspects disclosed herein are not to beconsidered as limiting.

In the following discussion, “distal” refers to a direction generallytoward an end of a system adapted for contact with a container, such asa vial, and “proximal” refers to the opposite direction of distal, i.e.,away from the end of a system adapted for contact with the container.For purposes of this disclosure, the above-mentioned references are usedin the description of the components of a system in accordance with thepresent disclosure.

Referring to FIGS. 1 and 2, one aspect of a system 10 for the closedtransfer of fluids includes a syringe adapter 12, a vial adapter 14, anda patient connector 16. The system 10 provides substantially leak-proofsealing during transfer of a fluid from a first container 18, such as avial, to a second container (not shown), such as a syringe, IV bag, orpatient IV line. The leak-proof sealing of the system 10 substantiallyprevents leakage of both air and liquid during use of the system 10.Although not shown, the system may further include an IV bag adapter aswell as other components typically utilized in closed system transferdevices, such as infusion lines and extension sets

Referring to FIGS. 3-14, one aspect of the syringe adapter 12 includes abody 22 having a first end 24 and a second end 26 and defining interiorspace 28. The first end 24 of the body 22 of the syringe adapter 12includes a syringe attachment 30, such as a female luer connector, thatdefines a passageway 32. Although a female luer connector is shown forconnection with a corresponding male luer connector of a syringe (notshown), other suitable connection arrangements may be utilized forconnection to a syringe, container, or any other medical device. Acannula 34 having a distal end 36 is secured to the syringe attachment30 and in fluid communication with the passageway 32 of the syringeattachment 30. The syringe adapter 12 further includes a sealarrangement 38 positioned within the body 22 of the syringe adapter 12.The seal arrangement 38 includes a membrane carrier 40 that receives afirst membrane 42 and a second membrane 44 spaced from the firstmembrane 42. The seal arrangement 38 further includes a biasing member46, such as a compression spring, that engages the membrane carrier 40and the syringe attachment 30 (or the body) and is configured to biasthe membrane carrier 40 toward the second end 26 of the syringe adapter12. The body 22 of the syringe adapter 12 may include structure toenhance gripping of the syringe adapter 12 by a user. In particular, thebody 22 of the syringe adapter 12 includes a plurality of annulargrooves 48 that extend around the circumference of the body 22 of thesyringe adapter 12, which enhances the ability of a user to grip thesyringe adapter 12. The body 22 of the syringe adapter 12 also includesa plurality of recessed portions adjacent to the first end 24 of thesyringe adapter 12 that extend in a longitudinal direction and aroundthe circumference of the body 22. Additional or alternative gripstructures and surfaces may be provided to assist a user in gripping thebody 22 of the syringe adapter 12.

Upon engagement of the second membrane 44 by a corresponding membraneduring use, the membrane carrier 40 is configured to move towards thefirst end 24 of the syringe adapter 12 such that the distal end 36 ofthe cannula 34 pierces the second membrane 44 to place the syringeadapter 12 in fluid communication with the corresponding device securedto the syringe adapter 12, as discussed below in more detail. After thesecond membrane 44 is disengaged from the corresponding membrane, themembrane carrier 40 is biased back to its original position therebypositioning the distal end 36 of the cannula 34 between the first andsecond membranes 42, 44. In FIG. 10, the membrane carrier 40 is shownafter being moved toward the first end 24 of the syringe adapter 12 withthe distal end 36 of the cannula 34 piercing the second membrane 44.However, the membrane carrier 40 will only be in the position shown inFIG. 10 after engagement with the vial adapter 14 or the patientconnector 16.

Such an arrangement shields the distal end 36 of the cannula 34 toprevent accidental needle sticks and also prevents the leakage of anyfluid during transfer of fluids when using the syringe adapter 12.Although the biasing member 46 is shown as a compression spring, anyother suitable biasing arrangement may be utilized to bias the membranecarrier 40 towards the second end 26 of the syringe adapter 12. Further,although the seal arrangement 38 includes first and second membranes 42,44 and the membrane carrier 40, any other suitable arrangement forsealing and shielding the cannula 34 during use may be utilized.

Referring again to FIGS. 3-14, the second end 26 of the syringe adapter12 includes a first connection interface 50 that includes a lock member52 that is received within a transverse opening 54 in the body 22 of thesyringe adapter 12. The lock member 52 is configured to move between aclosed position and an open position. The lock member 52 defines acentral opening 56 and includes a button 58 that is configured to beengaged by a hand of a user or operator of the syringe adapter 12. Thelock member 52 further includes a cantilever spring 60 that extends in alongitudinal direction of the syringe adapter 12. The lock member 52 isconfigured to engage a cam surface 62 that extends radially outward fromthe body 22 of the syringe adapter 12. In particular, the lock member 52is configured to be provided in the closed position, where a portion ofthe lock member 52 adjacent to the central opening 56 of the lock member52 is positioned within the interior space 28 of the syringe adapter 12when no external forces are applied to the lock member 52. When the lockmember 52 is moved to the open position where the central opening 56 ofthe lock member 52 is aligned with the interior space 28 of the syringeadapter 12 or does not create an interference or barrier to objectsbeing inserted into the interior space 28, as discussed in more detailbelow, the cantilever spring 60 engages the cam surface 62 to create abiasing force that urges the lock member 52 back towards the closedposition. Accordingly, when the lock member 52 is moved to the openposition, the lock member 52 will be urged back to the closed positionwhen the external force acting on the lock member 52 is released.Although the lock member 52 is shown with the cantilever spring 60, anyother suitable biasing member may be provided including, but not limitedto, compression springs, extension springs, elastomeric material, etc.

Referring to FIG. 11, the lock member 52 further includes a pair ofprojections 64 that extend radially outward from the lock member 52. Thepair of projections 64 is configured to engage corresponding projections66 provided on the body 22 of the syringe adapter 12 to retain the lockmember 52 to the body 22 of the syringe adapter 12. In other words, theprojections 64 of the lock member 52 are configured to engage theprojections 66 of the body 22 of the syringe adapter 12 to prevent thelock member 52 from being disconnected and removed from the transverseopening 54 of the body 22 of the syringe adapter 12. Referring to FIG.13, the lock member 52 further includes a pair of projections 65 thatextend axially upward from the lock member 52. The pair of axiallyextending projections 65 may further include a curved portion thatengages the external surface of the syringe adapter when the lock memberis in the open position, as shown in FIGS. 5 and 8.

Referring to FIG. 14, the lock member 52 further includes a lead-insurface 68 that is a concave-shaped depression on the bottom of the lockmember 52. As discussed below, the lead-in surface 68 is configured toengage a corresponding connection interface to transition the lockmember 52 from the closed position to the open position.

Referring to FIGS. 15-19, the vial adapter 14 includes a body 80 havinga first end 82 and a second end 84. The first end 82 includes a secondconnection interface 90 that is configured to mate with and lock withthe first connection interface 50 of the syringe adapter 12. The secondend 84 includes a spike member 92 that is configured to pierce the vialor container 18. The spike member 92 defines a fluid channel 94 and avent channel 96. The fluid channel 94 is in fluid communication with apassageway 98 extending through the second connection interface 90. Thevent channel 96 is in fluid communication with a pressure equalizationdevice 102, such as a balloon-type or bellows-type pressure equalizationarrangement, although any suitable pressure equalization arrangement 102may be utilized. The pressure equalization arrangement 102 is configuredto maintain the pressure within the vial 18 during fluid transfer toprevent the vial 18 from being pressurized or place in a vacuum. Thesecond end 84 of the vial adapter 14 also includes a vial attachment 104to secure the vial adapter 14 to the vial 18 or other container.

Referring still to FIGS. 15-19, the second connection interface 90includes a generally cylinder-shaped body 106 that defines a lockingsurface 108. The second connection interface 90 further includes alead-in surface 110. The lead-in surface 110 of the second connectioninterface 90 projects radially outward from the body 106 of the secondconnection interface 90 and defines a rounded transition between thebody 106 and the lead-in surface 110. The lead-in surface 110 ispositioned intermediate the ends of the second connection interface 90,although any other suitable position may be utilized. The lockingsurface 108 is a ring-shaped recess that is recessed relative to thelead-in surface 110 and configured to receive the lock member 52 of thefirst connection interface 50. The locking surface 108 is defined by 90degree angles, although other suitable shapes and angles may beutilized. The second connection interface 90 receives a membrane 112that closes the passageway 98 of the second connection interface 90. Thesecond connection interface 90 is configured to be received within theinterior space 28 of the syringe adapter 12 when the lock member 52 ofthe first connection interface 50 is in the open position and restrictedfrom moving within the interior space 28 of the syringe adapter 12 whenthe lock member 52 is in the closed position. The lead-in surface 110 ofthe second connection interface 90 is configured to engage the lockmember 52 of the first connection interface 50 to further move the lockmember 52 and further bias the cantilever spring 60. When the secondconnection interface 90 is fully mated to the first connection interface50, the lock member 52 of the first connection interface 50 isconfigured to be in the closed position and received within the lockingsurface 108 to lock the first connection interface 50 from longitudinaland transverse movement relative to the second connection interface 90,but still allowing rotational movement relative thereto.

Referring to FIGS. 20-21, the patient connector 16 includes a body 120having a first end 122 and a second end 124 and defining a passageway126 that extends therethrough. The first end 122 of the patientconnector 16 also includes the second connection interface 90 that isthat same as the second connection interface of the vial adapter 14.Accordingly, the second connection interface 90 of the patient connector16 includes the same features of the second connection interface 90 ofthe vial adapter 14 described above and cooperates with the firstconnection interface 50 in the same manner. The second end 124 of thepatient connector 16 includes an IV line attachment 128, such as a maleluer connector, although any other suitable connection arrangements maybe utilized.

Referring to FIGS. 22-24, the process of mating the first connectioninterface 50 with the second connection interface 90 is shown. Althoughthe syringe adapter 12 with the first connection interface 50 is shownbeing attached to the vial adapter 14 with the second connectioninterface 90, the connection of the first connection interface 50 withthe second connection interface 90 will be similar regardless of thedevices incorporating the first and second connection interfaces 50, 90.As shown in FIG. 22, the interior space 28 of the syringe adapter 12 isaligned with the second connection interface 90 of the vial adapter 14.In particular, the longitudinal axis of the syringe adapter 12 isaligned with the longitudinal axis of the vial adapter 14 and the lockmember 52 of the first connection interface 50 is in the closedposition. As shown in FIG. 23, the first connection interface 50 and thesecond connection interface 90 are moved towards each other with aportion of the second connection interface 90 being received within theinterior space 28 of the syringe adapter 12. At this position, thelead-in surface 68 of the lock member 52 of the first connectioninterface 50 engages the second connection interface 90, whichtransitions the lock member 52 from the closed position (shown in FIG.22) to the open position (shown in FIG. 23). When the lock member 52 ismoved from the closed position to the open position, the cantileverspring 60 will engage the cam surface 62 of the body 22 of the syringeadapter 12, which creates a biasing force that urges the lock member 52back to the closed position. Such movement back to the closed position,however, is prevented by engagement of the lock member 52 with the body106 of the second connection interface 90. With the lock member 52 ofthe first connection interface 50 in the open position, the secondconnection interface 90 is allowed to continue its movement within theinterior space 28 of the syringe adapter 12 to continue the process ofmating the syringe adapter 12 to the vial adapter 14 and to move thefirst connection interface 50 and the second connection interface 90towards a locked engagement.

Referring to FIGS. 23-24, after the lock member 52 of the firstconnection interface 50 is moved to the open position, the membrane 112of the second connection interface 90 engages the second membrane 44 ofthe seal arrangement 38 of the syringe adapter 12 thereby forming aliquid tight seal during fluid transfer between the syringe adapter 12and the vial adapter 14. Further insertion of the second connectioninterface 90 within the interior space 28 of the syringe adapter 12moves the membrane carrier 40 toward the first end 24 of the syringeadapter 12 against the biasing force of the biasing member 46 and causescannula 34 to pierce the second membrane 44 of the seal arrangement 38of the syringe adapter 12 and the membrane 112 of the second connectioninterface 90 thereby placing the vial adapter 14 in fluid communicationwith the syringe adapter 12. When the second connection interface 90 isinserted a predetermined distance within the interior space 28 of thesyringe adapter 12, the lead-in surface 110 of the second connectioninterface 90 engages the lock member 52 to further compress thecantilever spring 60. With further movement, the locking surface 108 ofthe second connection interface 90 will be aligned with the lock member52 of the first connection interface 50 such that the lock member 52 isreceived within the locking surface 108. In particular, the lock member52 is biased towards the closed positioned by the cantilever spring 60and when the lock member 52 reaches the locking surface 108, the lockmember 52 is free to move into the closed position where a portion ofthe lock member 52 is positioned within the interior space 28 of thesyringe adapter 12.

In the position shown in FIG. 24, the first connection interface 50 isfully mated and locked with respect to the second connection interface90. In such a position, the syringe adapter 12 is prevented from beingdisconnected from the vial adapter 14 due to the engagement between thelock member 52 of the first connection interface 50 and the lockingsurface 108 of the second connection interface 90. Although the lockedengagement between the first connection interface 50 and the secondconnection interface 90 prevents axial and transverse movement relativeto each other, the first connection interface 50 and the secondconnection interface 90 are free to rotate relative to each when lockedto each other, which advantageously prevents IV line tangling and/orother accidental disengagement or device failure associated with lack ofrotation between components. In particular, the patient connector 16,which is mated with and locked to the syringe adapter 12 in the samemanner as described above in connection with the vial adapter 14, istypically attached to a patient IV line and the rotation of the firstconnection interface 50 relative to the second connection interface 90assists in prevent twisting of a patient IV line connected to thepatient connector 16. However, the first connection interface 50 and thesecond connection interface 90 may be provided with a keyed surfacearrangement to prevent such relative rotation if desired.

Referring again to FIGS. 22-24, in order to disconnect the firstconnection interface 50 from the second connection interface 90, thebutton 58 of the lock member 52 of the first connection interface 50 isengaged by a user and pushed radially inward to transition the lockmember 52 from the closed position to the open position. The secondconnection interface 90 can then be removed from the interior space 28of the syringe adapter 12 in the reverse order of the steps to connectthe first connection interface 50 to the second connection interface 90.When the second connection interface 90 is finally separated from thefirst connection interface 50, the lock member 52 is moved to the closedposition and the biasing member 46 of the seal arrangement 38 of thesyringe adapter 12 moves the membrane carrier 40 to its originalposition with the distal end 36 of the cannula 34 positioned between thefirst and second membranes 42, 44. Although the first and secondconnection interfaces 50, 90 are each provided with the lead-in surfaces68, 110, only one of the first and second connection interfaces 50, 90may be provided with a lead-in surface 68, 110. Furthermore, neither ofthe first and second connection interfaces 50, 90 may be provided withthe lead-in surfaces 68, 110, which will require the lock member 52 ofthe first connection interface 50 to be manually moved from the closedposition to the open position to allow mating of the first and secondconnection interfaces 50, 90. More specifically, the lock member 52 ofthe first connection interface 50 may be moved from the closed positionto the open position by engaging the button 58 of the lock member 52 andmoving the lock member 52 radially inward such that the lock member 52is moved to the open position thereby allowing the mating of the firstand second connection interfaces 50, 90.

Referring to FIGS. 25-27, a second aspect of a system 140 for the closedtransfer of fluids is provided. The system 140 is similar to the system10 shown in FIGS. 1 and 2 with like reference numbers used for likeelements. Rather than providing a lead-in surface that extends radiallyoutward and positioned intermediate the ends of the body of the secondconnection interface 90, the second connection interface 90 of thesystem 140 shown in FIGS. 25-27 includes a lead-in surface at the firstend of the second connection interface 90 adjacent the membrane. Thelead-in surface of the aspect shown in FIGS. 25-27 is embodied as aslight blend at the top of the connection interface 90 and assists inmoving the lock member 52 from the closed to the open position. Further,the body 22 of the syringe adapter 12 does not include any gripstructures.

Although not shown, the systems shown in FIGS. 1-27, may include one ormore indication arrangements to provide a user with feedback when theconnection interfaces are fully locked or separated. In particular, thebody 22 of the syringe adapter 12 may be provided with openings withinner and outer tubes that cover one another when the part is in thelocked position and not cover one another when the part is in theinitial or unlocked position. Alternatively, only one color changecomponent may be provided that is visible within the opening in the bodyof the syringe adapter 12 when the device is in the locked or unlockedposition. The first and second connection interfaces 50, 90 may also beprovided with one or more tactile or auditory indicators to provide anindication of the state of the connection between the first and secondconnection interfaces 50, 90. The indication arrangement may also beembodied as alignment lines, dots, symbols, words, or other suitableindicia to assist a user in operating the system. Furthermore, althoughthe seal arrangement 38 of the syringe adapter 12 includes a membranecarrier 40 and first and second membranes 42, 44, any other suitablearrangement for sealing and delivering a fluid may be provided.

Referring to FIG. 28, the position of the cantilever spring 60 of thelock member 52 and the cam surface 62 of the body 22 of the syringeadapter 12 may be reversed. For example, as shown in FIG. 28, the body22 of the syringe adapter 12 is formed with a biasing member 144, suchas a cantilever spring, that is configured to contact a cam surface 146provided on the lock member 52 of the first connection interface 50. Thelock member 52 operates in the same manner as described above inconnection with system 10.

Referring to FIG. 29, a further aspect of the second connectioninterface 90 is shown. The second connection interface 90 shown in FIG.29 is similar to aspects of the second connection interface shown inFIGS. 1-28 and described above. The second connection interface 90 ofFIG. 29, however, includes a lead-in surface 156 positioned adjacent tothe membrane 112 or first end of the second connection interface 90. Thelead-in surface 156 assists in moving the lock member 52 from the closedto the open position. The second connection interface 90 shown in FIG.29 is provided in connection with a vial adapter, although this aspectmay be utilized in connection with any medical device and any componentof a system for the closed transfer of fluids.

While this disclosure has been described as having exemplary designs,the present disclosure can be further modified within the spirit andscope of this disclosure. This application is therefore intended tocover any variations, uses, or adaptations of the disclosure using itsgeneral principles. Further, this application is intended to cover suchdepartures from the present disclosure as come within known or customarypractice in the art to which this disclosure pertains and which fallwithin the limits of the appended claims.

What is claimed is:
 1. A system comprising: a syringe adapter having afirst end and a second end, the first end of the syringe adapterconfigured to be connected to a first container, the second end of thesyringe adapter includes a lock member having an open position and aclosed position; and a vial adapter having a first end and a second end,the second end of the vial adapter configured to be connected to asecond container, the first end of the vial adapter having a lockingsurface, the syringe adapter configured to be mated with the vialadapter when the lock member is in the open position, the syringeadapter configured to be locked to the vial adapter when the lock memberis in the closed position and positioned adjacent to the lockingsurface, wherein the lock member includes at least one projection thatextends radially outward and at least one projection that extendsaxially, wherein the axial projection is configured to engage anexternal surface of the syringe adapter when the lock member is in theopen position and wherein the syringe adapter includes at least onecorresponding projection configured to engage the at least one radiallyextending projection of the lock member to retain the lock member to thesyringe adapter.
 2. The system of claim 1, further comprising: a patientconnector having a first end and a second end and defining a passageway,the first end of the patient connector including a locking surfaceconfigured to engage the lock member of the syringe adapter, the secondend of the patient connector configured to be secured to a patient IVline.
 3. The system of claim 1, wherein the syringe adapter comprises abody and a seal arrangement positioned within the body, the sealarrangement having at least one membrane and configured to move withinthe body of the syringe adapter.
 4. The system of claim 1, wherein thevial adapter comprises a pressure equalization arrangement and a spike.5. The system of claim 3, wherein the body of the syringe adapterdefines an opening extending transversely relative to a longitudinalaxis of the syringe adapter that receives the lock member, the lockmember configured to move relative to the body of the syringe adapterbetween the open position and the closed position.
 6. The system ofclaim 5, wherein the lock member comprises a biasing member that isconfigured to bias the lock member towards the closed position.
 7. Thesystem of claim 6, wherein the lock member comprises a lead-in surfacethat is configured to contact the second end of the vial adapter andmove the lock member from the closed position to the open position whenthe syringe adapter is mated with the vial adapter.
 8. The system ofclaim 6, wherein the biasing member of the lock member comprises acantilever spring, the body of the syringe adapter defining a camsurface configured to engage the cantilever spring of the lock member.9. The system of claim 8, wherein the cantilever spring extends in anaxial direction, and wherein the cam surface extends radially outwardfrom the body of the syringe adapter.
 10. The system of claim 3, whereinthe at least one radial projection of the lock member comprises a pairof radially extending projections positioned on opposite sides of thelock member, and wherein the at least one corresponding projection ofthe syringe adapter comprises a pair of corresponding projectionsconfigured to engage the pair of projections of the lock member.
 11. Thesystem of claim 10, wherein the lock member is annular and receivedwithin an opening defined by the body of the syringe adapter, theopening of the syringe adapter extending transversely relative to alongitudinal axis of the syringe adapter.
 12. The system of claim 1,wherein the lock member comprises a button that is configured to beengaged by a hand of a user of the syringe adapter to move the lockmember from the closed position to the open position.
 13. The system ofclaim 3, wherein the seal arrangement comprises a membrane carrierhaving a membrane, the first end of the vial adapter having a membraneconfigured to engage the membrane of the membrane carrier.
 14. Thesystem of claim 13, wherein the membrane carrier is biased toward thesecond end of the syringe adapter via a biasing member.
 15. The systemof claim 1, wherein the first end of the syringe adapter includes afemale luer connector configured to be secured to a syringe.
 16. Thesystem of claim 12, wherein the at least one axial projection of thelock member comprises a pair of axially extending projections positionedadjacent the button.
 17. The system of claim 16, wherein the pair ofaxially extending projections further comprise a curved portion toengage the external surface of the syringe adapter for preventinglateral movement of the lock member when the lock member is in the openposition.